Among transgender adolescents in Canada, 97.1% continued with a gender not typically aligned with their birth sex, with only 1.1% discontinuing gender-affirming hormone treatment.

Shifts in gender-affirming medical requests by gender-diverse youth may not be uncommon during the adolescent's gender discernment process, and may more likely occur among nonbinary youth.

Smoking greatly increases the risk of COVID-19 mortality and morbidity in young adults

Study of Canadian transgender youth finds that trans youth are more likely to report self-harm, major depressive episodes, and suicide; 65% of transgender 14- to 18-year olds seriously considered suicide in the past year