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Decreasing epistaxis, or nosebleed, severity in patients with blood disorder, Hereditary Hemorrhagic Telangiectasia, using Pomalidomide, a bone marrow cancer drug

8 days ago nejm.org cancer medicine

One-quarter of unresponsive people with brain injuries are conscious

47 days ago nejm.org brain neuroscience

Increased use of blood transfusions after major traumatic brain injury could help people hospitalised in intensive care units regain greater functional independence and a better quality of life…

3 months ago nejm.org brain neuroscience

CRIPSR gene editing leads to improvements in vision for people with inherited blindness, clinical trial shows

4 months ago nejm.org health trial

Highly Pathogenic Avian Influenza A(H5N1) Virus Infection in a Dairy Farm Worker

5 months ago nejm.org

Large language models are poor medical coders

4 months ago ai.nejm.org

Researchers find that GPT-4 performs as well as or better than doctors on medical tests, especially in psychiatry

5 months ago ai.nejm.org medicine

Higher Incidence of autism spectrum disorder among children prenatally exposed to topiramate, valproate, or lamotrigine

5 months ago nejm.org autism medicine

COVID-19 leaves its mark on the brain, including with significant drops in IQ scores, study finds

6 months ago nejm.org brain covid health

Microplastics and Nanoplastics increase the risk of myocardial infarction, stroke, or death from any cause.

6 months ago nejm.org medicine

Tenecteplase therapy that was initiated 4.5 to 24 hours after stroke onset in patients with occlusions of the middle cerebral artery or internal carotid artery, most of whom had undergone endovascular thrombectomy, did not result in better clinical outcomes than those with placebo.

7 months ago nejm.org medicine

CAR T-cell therapy seems feasible, safe, and efficacious for patients with different autoimmune diseases, according to a new study

7 months ago nejm.org medicine

HIV-1 Remission after Allogeneic Hematopoietic-Cell Transplantation

7 months ago nejm.org medicine

Live, Attenuated, Tetravalent Butantan–Dengue Vaccine in Children and Adults

8 months ago nejm.org medicine vaccine

Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection | NEJM

7 months ago nejm.org health

Ultrasound Blood–Brain Barrier Opening and Aducanumab in Alzheimer’s Disease

9 months ago nejm.org disease health

Aspirin-Clopidogrel treatment up to 72 Hours after Ischemic Stroke led to a lower risk of new stroke at 90 days than aspirin therapy alone

9 months ago nejm.org medicine

Botox’s paralysing effects can relieve an uncontrolled head tremor

10 months ago nejm.org medicine

Novo Nordisk study finds that semaglutide (Wegovy) reduces risk of serious cardiovascular events such as heart attacks by 20% in overweight patients with a history of cardiovascular disease and no history of diabetes

10 months ago nejm.org diabetes disease medicine

Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea | NEJM

11 months ago nejm.org genetics malaria

Urinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events

11 months ago nejm.org

A potential cure for sickle cell disease: Researchers used CRISPR-Cas9 to edit genes in stem cells taken from 3 sickle cell disease patients to increase production of fetal hemoglobin (HbF)

13 months ago nejm.org disease medicine

Over half of cases of heart disease, and a fifth of deaths from any cause, may be attributable to 5 modifiable risk factors: body mass index, systolic blood pressure, non–high-density lipoprotein cholesterol, current smoking, and diabetes, finds new study based on data from 34 countries (n=1.5m).

13 months ago nejm.org diabetes disease medicine

New research uncovered evidence that the thymus is critical for adult health and for preventing cancer and autoimmune disease

14 months ago nejm.org cancer disease medicine

The diabetes and weight loss drug semaglutide significantly reduced symptoms and improved quality of life in people with obesity and the most common form of heart failure in a clinical trial, potentially expanding the drug’s use beyond diabetes and weight loss.

13 months ago nejm.org diabetes medicine trial

Two clinical trials of a selective sodium channel blocker (VX-548) showed that the agent reduced acute post-surgical pain compared to placebo

14 months ago nejm.org medicine

There was no significant differences in cognition and brain MRI outcomes over 3-year period for those on the MIND diet, a version of the Mediterranean diet, and those on a control diet with mild caloric restriction, finds new randomized, controlled trial of older adults without cognitive impairment.

14 months ago nejm.org brain neuroscience trial

Tetrahydrocannabinol and Cannabidiol in Tourette Syndrome - treatment with THC and CBD reduced tics and may reduce impairment due to tics, anxiety, and obsessive-compulsive disorder” in those with Tourette Syndrome.

15 months ago evidence.nejm.org health

Overall Survival with Osimertinib in Resected EGFR-Mutated NSCLC

16 months ago nejm.org cancer

Effect of Donor Sex on Recipient Mortality in Transfusion

17 months ago nejm.org medicine

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Decreasing epistaxis, or nosebleed, severity in patients with blood disorder, Hereditary Hemorrhagic Telangiectasia, using Pomalidomide, a bone marrow cancer drug

One-quarter of unresponsive people with brain injuries are conscious

Increased use of blood transfusions after major traumatic brain injury could help people hospitalised in intensive care units regain greater functional independence and a better quality of life…

CRIPSR gene editing leads to improvements in vision for people with inherited blindness, clinical trial shows

Highly Pathogenic Avian Influenza A(H5N1) Virus Infection in a Dairy Farm Worker

Large language models are poor medical coders

Researchers find that GPT-4 performs as well as or better than doctors on medical tests, especially in psychiatry

Higher Incidence of autism spectrum disorder among children prenatally exposed to topiramate, valproate, or lamotrigine

COVID-19 leaves its mark on the brain, including with significant drops in IQ scores, study finds

Microplastics and Nanoplastics increase the risk of myocardial infarction, stroke, or death from any cause.

Tenecteplase therapy that was initiated 4.5 to 24 hours after stroke onset in patients with occlusions of the middle cerebral artery or internal carotid artery, most of whom had undergone endovascular thrombectomy, did not result in better clinical outcomes than those with placebo.

CAR T-cell therapy seems feasible, safe, and efficacious for patients with different autoimmune diseases, according to a new study

HIV-1 Remission after Allogeneic Hematopoietic-Cell Transplantation

Live, Attenuated, Tetravalent Butantan–Dengue Vaccine in Children and Adults

Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection | NEJM

Ultrasound Blood–Brain Barrier Opening and Aducanumab in Alzheimer’s Disease

Aspirin-Clopidogrel treatment up to 72 Hours after Ischemic Stroke led to a lower risk of new stroke at 90 days than aspirin therapy alone

Botox’s paralysing effects can relieve an uncontrolled head tremor

Novo Nordisk study finds that semaglutide (Wegovy) reduces risk of serious cardiovascular events such as heart attacks by 20% in overweight patients with a history of cardiovascular disease and no history of diabetes

Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea | NEJM

Urinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events

A potential cure for sickle cell disease: Researchers used CRISPR-Cas9 to edit genes in stem cells taken from 3 sickle cell disease patients to increase production of fetal hemoglobin (HbF)

Over half of cases of heart disease, and a fifth of deaths from any cause, may be attributable to 5 modifiable risk factors: body mass index, systolic blood pressure, non–high-density lipoprotein cholesterol, current smoking, and diabetes, finds new study based on data from 34 countries (n=1.5m).

New research uncovered evidence that the thymus is critical for adult health and for preventing cancer and autoimmune disease

The diabetes and weight loss drug semaglutide significantly reduced symptoms and improved quality of life in people with obesity and the most common form of heart failure in a clinical trial, potentially expanding the drug’s use beyond diabetes and weight loss.

Two clinical trials of a selective sodium channel blocker (VX-548) showed that the agent reduced acute post-surgical pain compared to placebo

There was no significant differences in cognition and brain MRI outcomes over 3-year period for those on the MIND diet, a version of the Mediterranean diet, and those on a control diet with mild caloric restriction, finds new randomized, controlled trial of older adults without cognitive impairment.

Tetrahydrocannabinol and Cannabidiol in Tourette Syndrome - treatment with THC and CBD reduced tics and may reduce impairment due to tics, anxiety, and obsessive-compulsive disorder” in those with Tourette Syndrome.

Overall Survival with Osimertinib in Resected EGFR-Mutated NSCLC

Effect of Donor Sex on Recipient Mortality in Transfusion