progscrape: nejm.org

A drug once designed for dengue virus, then quietly abandoned by industry, is suddenly back in the spotlight

6 days ago nejm.org medicine

High-Dose Influenza Vaccine Effectiveness against Hospitalization in Older Adults

23 days ago nejm.org biology vaccine

Phase 3 trial in 18,746 adults finds Pfizer’s modRNA flu shot 34.5% more effective than standard vaccines for influenza A, while results for influenza B remain inconclusive, and mild to moderate side effects occur more often in the mRNA group.

42 days ago nejm.org medicine mrna trial

Early Discontinuation of Aspirin after PCI in Low-Risk Acute Myocardial Infarction.

35 days ago nejm.org health

Cognitive Biases and A.I. – shows worse biases than human practitioners

55 days ago ai.nejm.org ai

Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3

56 days ago nejm.org trial

Patients with advanced triple-negative breast cancer who are ineligible for immune checkpoint inhibitors lived longer without disease progression when treated with the antibody–drug conjugate sacituzumab govitecan, with a median progression-free survival of 9.7 vs 6.9 months.

2 months ago nejm.org cancer disease

A new study found that people who received medications for opioid use disorder while jailed were less likely to overdose, die, or return to jail after release.

3 months ago nejm.org health release

ECGFounder: An Electrocardiogram Foundation Model Built on over 10M Recordings

3 months ago ai.nejm.org

Commercial LLMs (GPT-4o, Gemini 1.5 Pro-002, Llama 3.1 8B Instruct), including after finetuning, showed poor average generalization accuracy (21-42%) when attempting to answer medical questions related to new drugs or updated recommendations

4 months ago ai.nejm.org llm medicine

First Complete Medical Evidence for the Use of Digitoxin (Digitalis Purpurea or Common Foxglove) Showing Positive Effects in Patients with Heart Failure and Reduced Ejection Fraction

4 months ago nejm.org medicine

Once-monthly maridebart cafraglutide resulted in substantial weight reduction in participants with obesity with or without type 2 diabetes, study shows

5 months ago nejm.org diabetes medicine

10 out of 12 people cured in Type 1 Diabetes Study

6 months ago nejm.org diabetes

U.S. Research Leadership at a Crossroads — The Impact of Reducing NIH Indirect-Cost Coverage

7 months ago nejm.org medicine

People overtrust AI-Generated medical advice. 300 participants evaluated AI and doctor-written medical advice

7 months ago ai.nejm.org ai

A new triple therapy for aggressive, advanced breast cancer delays the progression of the disease by 17.2 months on average, delays the need for further chemotherapy by 2 years and helps patients live longer.

7 months ago nejm.org cancer disease

Tirzepatide as Compared with Semaglutide results in around 50% more weight loss | NEJM

7 months ago nejm.org health

AI Detects Hidden Heart Disease: New VA Study Uses Chest CTs to Predict Risk

7 months ago ai.nejm.org ai disease medicine

Loss of Medicaid coverage linked to higher mortality among low-income older adults – The risks were particularly high among individuals with greater clinical needs and on more expensive medications.

7 months ago nejm.org health

Countries regulate healthcare AI differently. Predictive AI follows existing medical device rules while generative AI lacks clear standards

9 months ago ai.nejm.org ai

Associations Between Class I, II, or III Obesity and Health Outcomes

9 months ago evidence.nejm.org

A clinical trial found that Therabot, an AI therapy app, significantly reduced symptoms in patients with mental disorders over 8 weeks

9 months ago ai.nejm.org ai psychology trial

Intensive Blood-Pressure Control in Patients with Type 2 Diabetes | New England Journal of Medicine

9 months ago nejm.org diabetes health

New leukaemia treatment gets FDA approval, remission in 77% of patients who have failed two or more therapies. Low rate of side effects also observed.

11 months ago nejm.org cancer

Critical Illness in an Adolescent with Influenza A(H5N1) Virus Infection

12 months ago nejm.org medicine

AI Models Show Stronger Cognitive Biases Than Human Doctors When Making Treatment Decisions

12 months ago ai.nejm.org ai health

Global clinical trial shows improved survival rates for common childhood leukemia

13 months ago nejm.org health trial

Autonomous LLM-Driven Research — from Data to Human-Verifiable Research Papers

13 months ago ai.nejm.org

7/67 Children Receiving Skysona Gene Therapy Develop Blood Cancer

15 months ago nejm.org cancer

Lentiviral Gene Therapy for Cerebral Adrenoleukodystrophy found useful

15 months ago nejm.org medicine

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