progscrape: nejm.org

Botox’s paralysing effects can relieve an uncontrolled head tremor

18 months ago nejm.org medicine

Novo Nordisk study finds that semaglutide (Wegovy) reduces risk of serious cardiovascular events such as heart attacks by 20% in overweight patients with a history of cardiovascular disease and no history of diabetes

18 months ago nejm.org diabetes disease medicine

Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea | NEJM

19 months ago nejm.org genetics malaria

Urinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events

19 months ago nejm.org

A potential cure for sickle cell disease: Researchers used CRISPR-Cas9 to edit genes in stem cells taken from 3 sickle cell disease patients to increase production of fetal hemoglobin (HbF)

20 months ago nejm.org disease medicine

Over half of cases of heart disease, and a fifth of deaths from any cause, may be attributable to 5 modifiable risk factors: body mass index, systolic blood pressure, non–high-density lipoprotein cholesterol, current smoking, and diabetes, finds new study based on data from 34 countries (n=1.5m).

20 months ago nejm.org diabetes disease medicine

New research uncovered evidence that the thymus is critical for adult health and for preventing cancer and autoimmune disease

21 months ago nejm.org cancer disease medicine

The diabetes and weight loss drug semaglutide significantly reduced symptoms and improved quality of life in people with obesity and the most common form of heart failure in a clinical trial, potentially expanding the drug’s use beyond diabetes and weight loss.

20 months ago nejm.org diabetes medicine trial

Two clinical trials of a selective sodium channel blocker (VX-548) showed that the agent reduced acute post-surgical pain compared to placebo

21 months ago nejm.org medicine

There was no significant differences in cognition and brain MRI outcomes over 3-year period for those on the MIND diet, a version of the Mediterranean diet, and those on a control diet with mild caloric restriction, finds new randomized, controlled trial of older adults without cognitive impairment.

22 months ago nejm.org brain neuroscience trial

Tetrahydrocannabinol and Cannabidiol in Tourette Syndrome - treatment with THC and CBD reduced tics and may reduce impairment due to tics, anxiety, and obsessive-compulsive disorder” in those with Tourette Syndrome.

23 months ago evidence.nejm.org health

Overall Survival with Osimertinib in Resected EGFR-Mutated NSCLC

23 months ago nejm.org cancer

Effect of Donor Sex on Recipient Mortality in Transfusion

24 months ago nejm.org medicine

Decompressive Craniectomy versus Craniotomy for Acute Subdural Hematoma

2 years ago nejm.org health

Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections

2 years ago nejm.org medicine

Calorie Restriction with or Without Time-Restricted Eating in Weight Loss

2 years ago nejm.org

Anti-GD2 CAR T cell treatment in neuroblastoma patients shows definitive proof-of-concept for the use of CAR T cells to treat a solid tumor

2 years ago nejm.org medicine

Air Pollution and Mortality at the Intersection of Race and Social Class

2 years ago nejm.org environment

Delaying treatment for localized prostate cancer does not increase risk of death, study shows

2 years ago nejm.org cancer

Current causes of death in children and adolescents in the United States (2022)

2 years ago nejm.org

Two Phase 3 Trials of Lebrikizumab for Moderate-to-Severe Atopic Dermatitis

2 years ago nejm.org health

A single injection of a new COVID-19 antiviral treatment cut the risk of hospitalization for infection in half in clinical trials

2 years ago nejm.org covid health

Phase 3, randomized control trial (n=24,966) for single dose RSV vaccine (RSVPreF3 OA) was shown to be highly efficacious against severe disease and infection in older adults (60+) regardless of RSV subtype

2 years ago nejm.org disease medicine trial vaccine

A bivalent mRNA vaccine targeting omicron BA.4–BA.5 sublineages resulted in neutralization of other SARS-CoV-2 variants similar to that of a fourth dose of a monovalent mRNA vaccine.

2 years ago nejm.org mrna vaccine

Results from a study showed that a computerized simulated-driving program improved ADHD teen driving by reducing the rate of collisions/near-collisions post-training

2 years ago nejm.org

Lifting Universal Masking in Schools — Covid-19 Incidence among Students and Staff

2 years ago nejm.org covid

Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression | NEJM

2 years ago nejm.org psilocybin

Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death

2 years ago nejm.org cancer

Milestone: Tofersen reverses ALS weakness in some cases.

2 years ago nejm.org

The bivalent omicron-containing vaccine mRNA-1273.214 elicited neutralizing antibody responses against omicron that were superior to those with mRNA-1273, without evident safety concerns.

2 years ago nejm.org vaccine

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Botox’s paralysing effects can relieve an uncontrolled head tremor

Novo Nordisk study finds that semaglutide (Wegovy) reduces risk of serious cardiovascular events such as heart attacks by 20% in overweight patients with a history of cardiovascular disease and no history of diabetes

Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea | NEJM

Urinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events

A potential cure for sickle cell disease: Researchers used CRISPR-Cas9 to edit genes in stem cells taken from 3 sickle cell disease patients to increase production of fetal hemoglobin (HbF)

Over half of cases of heart disease, and a fifth of deaths from any cause, may be attributable to 5 modifiable risk factors: body mass index, systolic blood pressure, non–high-density lipoprotein cholesterol, current smoking, and diabetes, finds new study based on data from 34 countries (n=1.5m).

New research uncovered evidence that the thymus is critical for adult health and for preventing cancer and autoimmune disease

The diabetes and weight loss drug semaglutide significantly reduced symptoms and improved quality of life in people with obesity and the most common form of heart failure in a clinical trial, potentially expanding the drug’s use beyond diabetes and weight loss.

Two clinical trials of a selective sodium channel blocker (VX-548) showed that the agent reduced acute post-surgical pain compared to placebo

There was no significant differences in cognition and brain MRI outcomes over 3-year period for those on the MIND diet, a version of the Mediterranean diet, and those on a control diet with mild caloric restriction, finds new randomized, controlled trial of older adults without cognitive impairment.

Tetrahydrocannabinol and Cannabidiol in Tourette Syndrome - treatment with THC and CBD reduced tics and may reduce impairment due to tics, anxiety, and obsessive-compulsive disorder” in those with Tourette Syndrome.

Overall Survival with Osimertinib in Resected EGFR-Mutated NSCLC

Effect of Donor Sex on Recipient Mortality in Transfusion

Decompressive Craniectomy versus Craniotomy for Acute Subdural Hematoma

Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections

Calorie Restriction with or Without Time-Restricted Eating in Weight Loss

Anti-GD2 CAR T cell treatment in neuroblastoma patients shows definitive proof-of-concept for the use of CAR T cells to treat a solid tumor

Air Pollution and Mortality at the Intersection of Race and Social Class

Delaying treatment for localized prostate cancer does not increase risk of death, study shows

Current causes of death in children and adolescents in the United States (2022)

Two Phase 3 Trials of Lebrikizumab for Moderate-to-Severe Atopic Dermatitis

A single injection of a new COVID-19 antiviral treatment cut the risk of hospitalization for infection in half in clinical trials

Phase 3, randomized control trial (n=24,966) for single dose RSV vaccine (RSVPreF3 OA) was shown to be highly efficacious against severe disease and infection in older adults (60+) regardless of RSV subtype

A bivalent mRNA vaccine targeting omicron BA.4–BA.5 sublineages resulted in neutralization of other SARS-CoV-2 variants similar to that of a fourth dose of a monovalent mRNA vaccine.

Results from a study showed that a computerized simulated-driving program improved ADHD teen driving by reducing the rate of collisions/near-collisions post-training

Lifting Universal Masking in Schools — Covid-19 Incidence among Students and Staff

Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression | NEJM

Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death

Milestone: Tofersen reverses ALS weakness in some cases.

The bivalent omicron-containing vaccine mRNA-1273.214 elicited neutralizing antibody responses against omicron that were superior to those with mRNA-1273, without evident safety concerns.