progscrape: nature.com

First for RNA therapy: man with rare motor-neuron disease, also called ALS, improves after treatment and continued to work as a physician a year after becoming the first person to receive a drug designed to target the specific genetic mutation that causes his disease.

2 days ago nature.com biology disease genetics neuroscience

Intestinal infections cause antigen-specific CD4+ T cells to migrate from the gut and establish long-lived memory in the brain and meninges, a mechanism the authors link to anxiety and depression in inflammatory bowel disease

4 hours ago nature.com brain disease health

Cholesterol maintains the degradative capacity of lysosomes during clearance and recycling of dysfunctional mitochondria

5 days ago nature.com medicine

Defining collectivism as duties in relationships rather than generalized warmth improves predictive validity in 100 cultures

5 days ago nature.com

Ca 5% of white adults in the US support white nationalism, but among young white men, it's 13.5%

5 days ago nature.com

Prenatal cannabis exposure was associated with alterations in large-scale functional brain network connectivity in late childhood, higher levels of psychopathology and significant differences across multiple cognitive domains, according to a study on 10,838 children (9-10 years)

2 hours ago nature.com brain cannabis neuroscience

Human brain cells transplanted into mice in ‘most extensive’ integration ever

5 days ago nature.com brain neuroscience

Deletion of a distal IRF4 element prevents inflammation-induced reprogramming of human regulatory T cell fate

16 hours ago nature.com health

In a US trial, teclistamab wiped out cancer completely in 78% of high risk myeloma patients, against 0% on standard treatment, and cut two year progression to 8%.

8 days ago nature.com cancer medicine trial

A divergent betacoronavirus with a functional furin cleavage site in South American bats

17 days ago nature.com biology

Teenage girls show higher prevalence of internalizing problems than boys: depressive symptoms (15.9% versus 8.2%) and suicidal ideation (29.8% versus 18.1%)

3 days ago nature.com health

Emergent blink rate in early childhood is associated with neural origins of executive function

2 days ago nature.com biology

Higher semaglutide dose is associated with lower neuropsychiatric event incidence independent of weight loss

16 days ago nature.com health

Researchers worry that generative AI is homogenizing culture and cognition

19 days ago nature.com ai

Targeting the best-connected buyers of green hydrogen makes subsidies up to 41% more cost-effective

32 hours ago nature.com

Nos1 neurons in the paraventricular hypothalamic area modulate lipid metabolism via the sympathetic nervous system in male mice

8 days ago nature.com biology

A review of 1,624 estimates since the 1970s found scientists still cannot agree how much water the world's farms actually draw for irrigation, and the guesses are getting worse, not better.

6 days ago nature.com

YAP1 induces hepatocellular carcinoma via DNA demethylation rather than by canonical driver gene mutationsh

4 days ago nature.com biology

A survey of 3,751 Syrian and Iraqi refugees found that drought made war's mental toll worse.

21 days ago nature.com anthropology

Using data from 10 countries, researchers find that the expansion of high-paying finance jobs is a major driver of rising geographic inequality, not simply the growth of big cities.

7 days ago nature.com economic

PQBP1-dependent alternative RNA splicing underlies high calorie diet-induced cognitive impairmentbv

2 days ago nature.com health

Pregnant mice crave food much as pregnant women report. Researchers traced it to serotonin brain cells that fire less during pregnancy.

2 days ago nature.com brain health

In a prospective study of 104,806 adults followed for a median 8.1 years, greater differences in meal timing between weekdays and weekends were associated with higher cardiovascular disease risk in men

17 days ago nature.com disease health

'Epigenetic' editing banishes hepatitis B virus

16 hours ago nature.com

Prevalence and chronology of colibactin-associated mutational processes and their microbiome spectra in Japanese colorectal cancer

15 days ago nature.com cancer japan

Two parallel neural ectoderm progenitors contribute to the developing brain

2 days ago nature.com brain neuroscience

Accelerometer data from 57 adults (and 17 wrist/hip data) tracked for 90 days suggests that participants with high cadence and high peak height in their gait were less likely to be depressed or anxious

5 days ago nature.com health

Intratumoral T cell activation kills tumors regardless of T cell specificity | Nature Immunology

13 days ago nature.com cancer

Modelling over 16,000 groundwater samples, researchers found wells near land vulnerable to shale gas spills were three times more likely to carry deep drilling fluid chemicals.

12 days ago nature.com

The structure and lasting impact of the Roman road system