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A new antimalarial compound can rapidly clear out malaria parasites in infected mice with a single dose while largely avoiding the development of treatment resistance.

3 years ago stm.sciencemag.org malaria

By combining components from tumor cell and bacterial cell membranes, scientists have engineered nanoparticle cancer vaccines that better strengthen immune responses against melanoma, colon…

3 years ago stm.sciencemag.org cancer

A new approach to treating breast cancer kills 95-100% of cancer cells in mouse models of human estrogen-receptor-positive breast cancers and their metastases in bone, brain, liver, and lungs

3 years ago stm.sciencemag.org brain cancer

Low doses of 'laughing gas' could be fast, effective treatment for severe depression

3 years ago stm.sciencemag.org

A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss found alternate-day fasting without energy restriction less effectively reduced body fat content and and offered no additional short-term improvements compared to daily energy restriction.

3 years ago stm.sciencemag.org trial

SVEP1 human gene is casually linked to atherosclerosis (clogged arteries/coronary disease) and is independent of cholesterol

3 years ago stm.sciencemag.org disease

Antidepressant drug Paroxetine found to be a disease-modifying treatment for Osteoarthritis

3 years ago stm.sciencemag.org

CRISPR-based genetic screening identifies KAT7 as a gene that drives aging in both premature aging and normal aging, with subsequent gene therapy extending healthspan and lifespan in both mice models

3 years ago stm.sciencemag.org genetics

COVID-19 Linked to Blood Clotting

4 years ago stm.sciencemag.org covid

Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study

4 years ago stm.sciencemag.org

A machine learning algorithm may be able to spot different types of cancers during their earliest, most treatable stages by studying changes in receptors on the body’s own TCells…

4 years ago stm.sciencemag.org algorithm

According to a new study, a nanoparticle RNA vaccine for the COVID-19 virus safely elicited the production of antibodies and T cell responses—with antibodies lasting more than 70 days—completely neutralizing the coronavirus.

4 years ago stm.sciencemag.org coronavirus covid vaccine

Hearing restored in rats by modifying ear cells to respond to light: Cochlear implants that restore hearing could be improved by genetically modifying the nerve cells in people’s ears so that they respond to light instead of electricity

4 years ago stm.sciencemag.org

Using CRISPER effectively to reverse diabetes-causing pathogenic variant in Wolfram syndrome 1: Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice

4 years ago stm.sciencemag.org diabetes wolfram

Some progress in pursuit of an anti-viral for SARS-Cov-2

4 years ago stm.sciencemag.org

Astrocyte molecular signatures in Huntington’s disease

4 years ago stm.sciencemag.org disease

Intravenous delivery of (rh)platelet-derived growth factor AB improves post-heart attack wound healing in large animal models via altering mechanics of the infarct scar which resulted in robust cardiac functional improvement…

4 years ago stm.sciencemag.org

Scientists present an approach to encode medical history on a patient using quantum dots in the skin, which are invisible to the naked eye yet detectable when exposed to near-infrared light…

4 years ago stm.sciencemag.org

A new oral contraceptive that only has to be taken once a month, could reduce unintended pregnancies that result from forgetting to take a daily dose

4 years ago stm.sciencemag.org

Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

5 years ago stm.sciencemag.org cancer

Mutant neuropeptide S receptor reduces sleep duration with preserved memory consolidation - Lijuan Xing1, Guangsen Shi, Yulia Mostovoy, Nicholas W

5 years ago stm.sciencemag.org

Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials

5 years ago stm.sciencemag.org cancer

Elite athletes were found to have an increase in Veillonella atypica, a specific strain of gut bacteria, in the days following completion of a marathon

5 years ago stm.sciencemag.org

Researchers develop an antibody that bridges T-cells to ovarian cancer cells, allowing the immune cell to eradicate ovarian tumors in preclinical models; currently being tested in Phase 1 trials

5 years ago stm.sciencemag.org cancer

Diagnosis of genetic diseases in seriously ill children by rapid whole-genome sequencing and automated phenotyping and interpretation

5 years ago stm.sciencemag.org genetics

Detecting cancer in plasma with cell-free DNA and their genome fragmentation signature

5 years ago stm.sciencemag.org cancer

Researchers have been on the hunt for new drugs to combat bacterial 'superbugs.' A new report describes success using gallium, a metal that bacteria confuse for iron, which they take up as a nutrient

6 years ago stm.sciencemag.org

Scientists have developed a chemical compound which produces morphine-like analgesic effects but also suppresses the addictive effects produced by prescription opioids.

6 years ago stm.sciencemag.org

An international team of researchers has uncovered a destructive mechanism at the molecular level that causes a well-known phenomenon associated with obesity, called leptin resistance

6 years ago stm.sciencemag.org

Germs gaining resistance to hand gels in hospitals: Increasing tolerance of hospital Enterococcus faecium to handwash alcohols

6 years ago stm.sciencemag.org