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Among ~294,000 US veterans aged 65+, Moderna's next-gen mRNA-1283 COVID-19 vaccine was associated with 36% lower risk of medically attended COVID-19 and 47% lower risk of COVID-19 hospitalization than Pfizer's BNT162b2 during the 2025-26 season

As newborn vitamin K nonreceipt in the US climbed from 3.1% to 6.8% over eight years, researchers found infants missing the shot face significantly higher risks of severe bleeding and mortality during their birth hospitalization.

Classroom accommodations for kids with ADHD did not help, but stimulant medication did

Black and Hispanic Medicare patients with dementia were 31% and 52% less likely than White patients to enter a nursing home with a dementia care unit after a hospital stay, but most of the gap closed when comparing patients at the same hospital.

A US study of 1,000 children and adolescents found that teenagers could be exposed to an estimated 10,107 food advertisements annually through digital media, compared with 1,427 for younger children

The same stimulus, in a different location: personalizing brain stimulation using magnetic resonance imaging allowed depression to go into remission much more quickly.

Percutaneous Coronary Intervention and Long-Term Outcomes in Stable Coronary Artery Disease: Extended Follow-Up of the COURAGE Randomized Trial

CAR T-cell therapy shows promising results for stiff person syndrome, a rare autoimmune disease, with 81% of patients experiencing clinically meaningful improvements in walking speed 16 weeks after a single treatment, according to a clinical trial published in JAMA Neurology

A study of 2,362 deceased former NFL players estimated that 75% had chronic traumatic encephalopathy (CTE) at death, compared with 0.6% in the general population

Around a third of people may be lying about symptoms to get antibiotics, including for their kids

Autism diagnoses are 2.2x more common among kids from the poorest neighbourhoods than the richest, and the gap keeps growing, a study of 2.3 million children in Ontario, Canada found

Medicare patients with dementia who had more annual wellness visits were more likely to start a dementia medication within a year, rising from 9.8% with no visits to 14.1% with three or more

ADHD is associated with > 4x higher risk for late-life cognitive impairment.

Study: Schoolwide phone bans show no significant impact on mental health

Owning a smartphone at age 12 was associated with a 103% higher risk of tying self-worth to weight, 67% higher risk of binge eating and 49% higher risk of any eating disorder symptoms by age 14…

Mortality Among People with Attention-Deficit/Hyperactivity Disorder

A US study of 1,981 FDA-approved drugs found the average number of patents per drug rose from 2.1 in 1990 to 6.9 in 2019, extending market exclusivity by six years on average.

A 1,000-patient JAMA trial shows cold-stored platelets (up to 21 days) are noninferior to standard room-temp platelets for active bleeding, potentially slashing waste and expanding availability.

A study of over 414,000 births found a substantially higher risk of infant mortality among infants born to mothers with depressive symptoms

Prognostic Value of Blood-Based P-Tau217 Levels for Progression to Cognitive Impairment

7-year cumulative ASD incidence remained stable across 12 consecutive birth cohorts

Polypharmacy and Drug-Drug Interactions Among Older Adults: Prescription polypharmacy (five or more concurrent prescriptions) increased from 31.0% to 35.7% while major drug interactions declined from 25.7% to 22.3%

Study of 4,884 men with nonmetastatic prostate cancer found those consuming the most saturated fat after diagnosis had a 24% higher risk of death, while replacing animal fats with plant-based fats was associated with a 16% lower risk of death.

GLP-1 drugs may improve obstructive sleep apnea through mechanisms beyond weight loss, including effects on breathing control, upper-airway neuromuscular function, and inflammation

Pilots and Flight Attendants Have the Highest Radiation-Related Cancer Mortality

Cognitive Behavior vs Bright Light Therapy for Insomnia in Women Undergoing Chemotherapy for Breast CancerA Randomized Clinical Trial

Systematic review of 155 studies finds updated COVID-19 vaccines provide meaningful protection against hospitalization and death, especially in older adults

Study of over 40,000 people receiving methadone treatment for opioid use disorder found take-home dosing was associated with lower mortality and treatment discontinuation than no take-home dosing, with the greatest benefits when initiated within 5 to 24 weeks after induction.

Medicare Advantage Enrollment and Access to Kidney Transplant: Medicare Advantage enrollment was associated with substantially lower rates of kidney transplant and wait-listing, highlighting the need for policy oversight to ensure access to this crucial treatment

Around half of people on semaglutide for obesity stop taking it early

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