Single-Dose Psilocybin Treatment for Major Depressive Disorder

Oregon launches legal psilocybin access amid high demand and hopes

"…found no detectable difference in altered states of consciousness induced by 20 mg psilocybin, 100 µg LSD, or 500 mg mescaline”, and no severe side effects were noted for any substance"

Review suggested that "psilocybin may be an effective form of treatment for cancer-related psychiatric distress, treatment-resistant depression and addiction" and that "there are some reports of psilocybin being useful when treating obsessive-compulsive disorder and cluster headaches."

Psilocybin Decelerates Cellular Senescence

A trial finds that a dose of the psychedelic psilocybin administered with psychological support is a safe and acceptable treatment for patients with anorexia nervosa and may decrease eating-disorder behaviours in some patients.

Psilocybin’s effects on cognition and creativity: A scoping review | Journal of Psychopharmacology [Jul 2023]

Australia to prescribe MDMA and psilocybin for PTSD and depression

A new study indicates that reductions in experiential avoidance play a significant role in the therapeutic effects of psilocybin-assisted therapy among depressed patients, leading to improvements in well-being and reductions in depression severity…

Spontaneous and deliberate creative cognition during and after psilocybin (2021)

Psychotherapy with Psilocybin for Depression: Systematic Review

Australia the First Nation to Approve the Legal Use of MDMA and Psilocybin

Psilocybin-enhanced group psychotherapy for depression shows promise in patients with cancer

The mechanism of psilocybin therapy: With psilocybin therapy, but not escitalopram, improvements in mental health outcomes (i.e., well-being, depression severity, suicidal ideation, and trait anxiety) occurred via reductions in experiential avoidance.

Patients tend to have a stronger brain response to music the day after receiving psilocybin-assisted therapy, according to new research

Preliminary study reveals potential of psilocybin for cluster headache treatment

A study of psilocybin reducing alcohol consumption in male mice was recently published in Frontiers in Pharmacology

A recent study of people who have used LSD or psilocybin found that "positive changes were observed across all 17 outcome items, with the strongest benefits on items related to insight and mood."

Psilocybin appears to have a uniquely powerful relationship with nature relatedness

Scientists are finally taking a serious look at psilocybin for the treatment of cluster headaches

Australia to allow prescription of MDMA and psilocybin mushrooms

MDMA and psilocybin are approved as medicines in Australia

Scientists are beginning to unravel the effects of psilocybin mushrooms on bipolar disorder: Findings indicate that many people with bipolar disorder who consume psilocybin, the primary psychoactive component of psychedelic “magic mushrooms,” believe that the experience is helpful.

Intensity of psychedelic experiences after taking psilocybin does not depend on body mass index, study suggests

Up to 9% of LSD and psilocybin users report reoccurring effects after drug has worn off

Single-dose psilocybin-assisted therapy in major depressive disorder: A placebo-controlled, double-blind, randomised clinical trial

Magic mushroom compound psilocybin can help treat depression, study finds

Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression | NEJM

Lasting increases in trait mindfulness after psilocybin correlate positively with the mystical-type experience in healthy individuals

Natural language signatures of psilocybin microdosing

More →