Escitalopram significantly reduced anger and irritability in people with premenstrual dysphoric disorder (PMDD), according to new research, providing further evidence that the antidepressant may help alleviate some of the condition's most disruptive emotional symptoms.

First human trial of psilocin since the 1960s reveals better tolerability than psilocybin

In a US trial, teclistamab wiped out cancer completely in 78% of high risk myeloma patients, against 0% on standard treatment, and cut two year progression to 8%.

In a trial of 948 people with stomach cancer in 20 countries, adding durvalumab to chemotherapy before and after surgery cut the risk of dying by 22% versus chemo alone.

Retatrutide-Associated Improvements in Cardiovascular Risk Biomarkers in Adults With Obesity With or Without Type 2 Diabetes

Formally recognizing insulin resistance as a distinct disease, rather than just a risk factor, would facilitate earlier diagnosis and standardized treatment.

A trial of 6,238 heart attack survivors in France found stopping beta blockers about as safe as staying on them: 17.2% who stopped had a problem, versus 15.9% who stayed.

In Uganda, 1,784 children under 2 got yellow fever vaccine at full, half or one fifth strength

MIT used AI to develop new recipe for mRNA vaccines so they no longer need freezers and can sit at room temp for a full year or survive about 100F heat for two months which could finally let these vaccines reach poor countries without cold storage and even work as easy skin patches instead of shots.

Treatment of Kratom Withdrawal and Dependence With Buprenorphine/Naloxone: A Case Series and Systematic Literature Review

[JAMA Psychiatry] The EPIsoDE randomized clinical trial of psilocybin for treatment-resistant depression yields inconclusive primary results, finding no statistically significant difference in 6-week response rates between 25 mg psilocybin (17%) and active placebo (10.6%).

Systematic review of 155 studies finds updated COVID-19 vaccines provide meaningful protection against hospitalization and death, especially in older adults

Vaccine protects against multiple fungal infections without hurting gut: Naturally occurring fungi and bacteria in gut microbiome unharmed by new pan-fungal vaccine that achieved protective immunity in primates against life-threatening fungal infections that kill millions each year.

A Czech trial of 558 people with dangerous lung clots found feeding clot dissolving drugs straight into the lung artery cut deaths and repeat clots to under 1%…

Magnetic Mitohormesis May Represent a Non-Invasive Restorative Therapy for X-Linked Muscular Dystrophies

Common genetic marker associated with faster Parkinson’s disease progression: People who carried the Melanocortin 1 receptor (MC1R) loss-of-function variants experienced 30% to 50% faster motor decline than non-carriers across two independent cohorts

A "living medicine" made from genetically engineered cells restored bone strength in 10 patients with advanced osteoporosis, according to early clinical results, offering a potential new approach to rebuilding weakened bones.

Loss of function of ALDH3B2 transdifferentiates human pancreatic duct cells into β-like cells | Science Translational Medicine

Alzheimer's Damage in Mice Reversed with Just Two Injections

Female brains wake up from anaesthesia differently than male brains

Molecular snapshots confirm ketamine’s opioid nature

Scientists find clearing cholesterol from blood also removes forever chemicals

Experimental Drug Makes Obese Mice Burn Fat Without Losing Muscle - Or Eating Less

Semaglutide linked to lower predicted dementia risk

Medical researcher who touted Covid ‘cure’ with hundreds of problematic ethical problems

Study ties estrogen-based menopausal hormone therapy to lower Alzheimer’s risk

New weight loss and diabetes treatment helps burn fat while keeping muscle

New discovery could 'disarm' one of the world's most dangerous fungal pathogens

Planned Parenthood urges New York to fund trans care for minors

A study examined psychiatric relapse after stopping antipsychotic medication during pregnancy

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